I’ve run into this issue a few times where Tribler fails to execute on Windows 10. I’m probably not the first to explain this, but I do have a solution.
Go to the %appdata%/roaming folder using Win + R by typing ‘appdata’ without quotes. Note: If you’ve modified your 2 config files previously, I would save them to the desktop before trying the next step.
Delete the .Tribler folder. Start Tribler and you will be presented with the opt-in or out message. This choice is yours to make. Close Tribler and it will recreate the .Tribler folder for you.
Go back to the .Tribler folder and replace your 2 config files saved on your desktop and restart Tribler. This should solve your issues.